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/ The body does its most intense "cleaning" while you are asleep

The smaller final step from 8mg to 12mg (a 50% increase rather than a 100% doubling) reflects the finding that GI tolerability improves at higher doses once the body has already adapted to substantial receptor activation

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First, translations of animal study data, then long-standing patterns established by experimental usage and mentioned in forums and lastly, specific protocols used by clinics and compounding pharmacies